反応式
[Si:1]([O:8][CH2:9][C:10]1[O:14][C:13]([C:15]#[N:16])=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH2:17][OH:18]>>[Si:1]([O:8][CH2:9][C:10]1[O:14][C:13]([C:15](=[N:17][OH:18])[NH2:16])=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]参加物
3
実験手順
The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 1 (1d) using 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-2-furonitrile (7.5 g, 32 mmol) that was obtained in Example 2 (2a) and a 40% aqueous solution of hydroxylamine (4.0 ml). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (1:1) as the eluent to afford the title compound (8.1 g) in a yield of 95% as a white crystalline solid.
後処理
- customthe similar reaction to
出典と根拠
- ORDレコード
- ord-6f32e31811f645beb923d1058b407bd3
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07687491B2
関連ノート
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