Peracetic Acid → Sulbactam

HRID 224788

反応式

HRID 224788 の反応式
[CH3:1][C:2]1([CH3:13])S[C@@H:5]2[CH2:7][C:8](=[O:9])[N:4]2[C@H:3]1[C:10]([OH:12])=[O:11].C(OO)(=O)C.[S:19](=[O:22])(O)[O-:20].[Na+]>O.C(OCC)(=O)C>[CH3:1][C:2]1([CH3:13])[S:19](=[O:22])(=[O:20])[C@@H:5]2[CH2:7][C:8](=[O:9])[N:4]2[C@H:3]1[C:10]([OH:12])=[O:11]

参加物

6

反応物 3

HCID 6585Peracetic Acid2 回HCID 6891Penicillanic AcidHCID 23665763Sodium Bisulfite

生成物 1

HCID 130313Sulbactam

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a stirred solution of 1.78 g. of penicillanic acid in water, at pH 7.5, was added 1.46 ml. of 40% peracetic acid, followed by an additional 2.94 ml. of 40% peracetic acid 30 minutes later. The reaction mixture was stirred for 3 days at room temperature and then it was diluted with ethyl acetate and water. Solid sodium bisulfite was added to decompose excess peracid, and then the pH was adjusted to 1.5. The ethyl acetate layer was removed, dried (Na2SO4) and evaporated in vacuo. The residue was a 3:2 mixture of penicillanic acid 1,1-dioxide and penicillanic acid 1-oxide.

後処理

  1. customThe ethyl acetate layer was removed
  2. dry with materialdried (Na2SO4)
  3. customevaporated in vacuo
  4. additiona 3:2 mixture of penicillanic acid 1,1-dioxide and penicillanic acid 1-oxide

出典と根拠

ORDレコード
ord-27f7b24ee1314ec1a204acc25be7bc42
出典データセット
uspto-grants-1980_11
特許番号
US04234579

関連ノート

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