ethyl p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoate → p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid

HRID 2247984ノート

反応式

HRID 2247984 の反応式
[CH3:1][C:2]1([CH3:26])[C:7]2[CH:8]=[CH:9][C:10]([C:12]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=3)=[O:13])=[CH:11][C:6]=2[S:5][CH2:4][CH2:3]1.[OH-].[K+].C(O)C.O>>[CH3:1][C:2]1([CH3:26])[C:7]2[CH:8]=[CH:9][C:10]([C:12]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=3)=[O:13])=[CH:11][C:6]=2[S:5][CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 19935413ethyl p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoateHCID 23714421Potassium hydroxide ethanol water

生成物 1

HCID 18990063p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid

実験手順

Hydrolysis of the foregoing ester with potassium hydroxide/ethanol/water in analogy to Example 57 gave p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid, melting point 274°-276° C.

出典と根拠

ORDレコード
ord-b347d3dc51fb4be89e17184d4d3aace6
出典データセット
uspto-grants-1991_08
特許番号
US05037825

反応ノート

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