Divinyl sulfone → Di(2-benzyl-3-phenyl-isoxazolidin-5-yl)Sulfone

関与物質

反応手順

A solution of 2.11 g (10 mmol) of N-benzylidenebenzylamine N-oxide and 1.09 g (5 mmol) of divinyl sulfone in 30 ml of toluene under a nitrogen atmosphere is heated at reflux temperature for 8 hours. The solvent is removed under reduced pressure to give 4.1 g of crude product which is then purified by preparative HPLC (Waters Prep 500A, silica gel, 3:1 heptane:ethyl acetate eluent) to give 0.70 g (26% yield) of a yellow amorphous solid.

情報源と証拠