化工社化工社 化学情報印刷レポート · 研究参考用
Methyl Acrylate → 2-Benzyl-3-phenyl-5-methoxycarbonylisoxazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Acrylate | HCID 7294 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Heptane | HCID 8900 | — |
| 反応物 | Benzenemethanamine,N-(phenylmethylene)-, N-oxide | HCID 305634 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Benzyl-3-phenyl-5-methoxycarbonylisoxazolidine | HCID 19816341 | 71% |
反応手順
A solution of 8.0 g (37.9 mmol) of N-benzylidenebenzylamine N-oxide and 6.69 g (77.7 mmol) of methyl acrylate in 20 ml of toluene is heated under reflux for 12 hours. The reaction mixture is evaporated under reduced pressure to give a pale yellow oil. Flash chromatography (silica gel, 2:1 heptane:ethyl acetate) affords 8.0 g of the title compound as a pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05037867 |
| 出典データセット | uspto-grants-1991_08 |
| ORD ID | ord-c165dc18008b4ca0bc18226b11441584 |
| 出典メモ | uspto-grants-1991_08 |