HCID 14990558、化合物 → HCID 14990559、化合物

HRID 2248310ノート

反応式

HRID 2248310 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH:17]([CH3:19])[CH3:18])=[C:12]([N+:20]([O-])=O)[CH:11]=2)=[O:9])=[CH:4][CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:20][C:12]1[CH:11]=[C:10]([C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:9])[CH:15]=[CH:14][C:13]=1[NH:16][CH:17]([CH3:18])[CH3:19]

参加物

5

反応物 2

HCID 14990558HCID 14990558、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 14990559HCID 14990559、化合物収率 92.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 14.7 parts of (4-fluorophenyl) [4-[(1-methylethyl)-amino]-3-nitrophenyl]methanone in 120 parts of ethanol was hydrogenated at 2.105Pa with 3 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated, yielding 12.3 parts (92.1%) of [3-amino-4-[(1-methylethyl)amino]phenyl] (4-fluorophenyl)-methanone as a residue (int. 2).

後処理

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-b2c0c0c6e34c42298d24f57700eb1e59
出典データセット
uspto-grants-1991_08
特許番号
US05039677

反応ノート

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