Morpholine → (4-Hydroxy-3,5-dimethylphenyl)acetic acid
反応式
C([C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([OH:11])=[C:6]([CH3:12])[CH:5]=1)(=O)C.[S].N1[CH2:19][CH2:18][O:17]CC1.[OH:20]CC[NH-]>>[OH:11][C:7]1[C:8]([CH3:10])=[CH:9][C:4]([CH2:19][C:18]([OH:17])=[O:20])=[CH:5][C:6]=1[CH3:12]参加物
5
実験手順
2-(4-Hydroxy-3,5-dimethylphenyl)acetic acid is prepared in a known way (cf. J. Org. Chem. 11, 798 (1946)) from 4-acetyl-2,6-dimethylphenol, sulfur, and morpholine (Willgeroth-Kindler Reaction) and has a melting point of 147° C. The acid is converted into the 2-hydroxyethylamide (yellow-brown oil) through the methyl ester (melting point 95° C.) by the method of Example 1.1.
出典と根拠
- ORDレコード
- ord-3c8dd07750914882917d110df1e42932
- 出典データセット
- uspto-grants-1991_08
- 特許番号
- US05039781
反応ノート
読み込み中…