Ethanol → 2-(Acetoxyacetylamino)-6-aminobenzamide

HRID 2248763ノート

反応式

HRID 2248763 の反応式
[C:1]([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[C:10]=1[C:11]#[N:12])=[O:7])(=[O:3])[CH3:2].C1CCCCC=1.C([OH:28])C>[C].[Pd]>[C:1]([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[C:10]=1[C:11]([NH2:12])=[O:28])=[O:7])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 702EthanolHCID 8079CyclohexeneHCID 149862822-(Acetoxyacetylamino)-6-nitrobenzonitrile

生成物 1

HCID 149862792-(Acetoxyacetylamino)-6-aminobenzamide

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

To a mixture of 2-(acetoxyacetylamino)-6-nitrobenzonitrile (5.7 g) and ethanol (50 ml) are added cyclohexene (10.5 ml) and 10% palladium-carbon (4.7 g). The mixture is refluxed for 20 minutes, and the reaction mixture is cooled to room temperature, and the solid materials are filtered off. The filtrate is distilled under reduced pressure. The residual crude crystals are recrystallized from ethanol to give the title compound (1.2 g) having the following physical properties.

後処理

  1. temperatureThe mixture is refluxed for 20 minutes
  2. filtrationthe solid materials are filtered off
  3. distillationThe filtrate is distilled under reduced pressure
  4. customThe residual crude crystals are recrystallized from ethanol

出典と根拠

ORDレコード
ord-3ea07f62c85c475d8ad9dfedc7d035e2
出典データセット
uspto-grants-1991_08
特許番号
US05041462

反応ノート

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