Dimethylformamide → HCID 178505787、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[C:15]([NH2:16])=[CH:14][N:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1.[C:17](=S)=[S:18].CN(C)C=O>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[C:17]([SH:18])=[N:16][C:15]3[C:10]2=[N:11][CH:12]=[N:13][CH:14]=3)=[CH:6][CH:7]=1参加物
5
実験手順
A mixture of 8.72 parts of N4 -[(4-fluorophenyl)methyl]-4,5-pyrimidinediamine, 63 parts of carbon disulfide and 45 parts of N,N-dimethylformamide was stirred for 3 hours at reflux temperature. After cooling, the reaction mixture was poured into water. The precipitated product was filtered off and dried, yielding 10.1 parts (78.9%) of 9-[(4-fluorophenyl)methyl]-9H-purine-8-thiol (interm. 24).
後処理
- temperatureat reflux temperature
- temperatureAfter cooling
- filtrationThe precipitated product was filtered off
- customdried
出典と根拠
- ORDレコード
- ord-440ba4b1364f48858b634c93868f19a2
- 出典データセット
- uspto-grants-1991_08
- 特許番号
- US05041448
反応ノート
読み込み中…