Sodium Bicarbonate → 1,3-Benzoxazole-2-carboxylic acid
反応式
C([O:4][C:5]([C:7]1[O:8][C:9]2[CH:15]=[CH:14][C:13](OCC3C=CC=C(OCC4C=CC5C(=CC=CC=5)N=4)C=3)=[CH:12][C:10]=2[N:11]=1)=[O:6])CC.C(=O)(O)[O-].[Na+]>C(O)C.O>[O:8]1[C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=[C:7]1[C:5]([OH:6])=[O:4]参加物
5
実験手順
A mixture of 0.64 g of n-propyl-5-(3-(quinolin-2-ylmethyloxy)benzyloxy)benzoxazole-2-carboxylate and 0.45 g of sodium bicarbonate in 20 ml of ethanol in 20 ml of water is refluxed for 1.5 hours, then stirred at room temperature overnight. The mixture is neutralized and the resulting solid is filtered off, washed with water and dried in vacuo to give 5-(3-quinolin-2-ylmethyloxy)-benzyloxy)benzoxazole-2-carboxylic acid.
後処理
- temperatureis refluxed for 1.5 hours
- filtrationthe resulting solid is filtered off
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-41f2617ba3ed4ebf9b51da2b22ccddd7
- 出典データセット
- uspto-grants-1991_08
- 特許番号
- US05041453
反応ノート
読み込み中…