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2-Nitropropane → 5-Bromo-3-(2-methyl-2-nitropropyl)indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Nitropropane | HCID 398 | — |
| 反応物 | Indole, 5-bromo-3-(dimethylamino)methyl- | HCID 13249 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 5-Bromo-3-(2-methyl-2-nitropropyl)indole | HCID 12619661 | — |
反応手順
5-Bromogramine, 60.0 g., 165 g. of 2-nitropropane, and 10.5 g. of sodium hydroxide pellets were caused to react under the conditions of Procedure 67C. The product was recovered as a dark syrup-like liquid from which the crystalline product was obtained by dissolving in IPr2O. The crystalline material was recrystallized from IPr2O to yield 48.6 g. of tan crystalline product, m.p. 106°-109°. The structure was confirmed by examination of the NMR spectrum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04234595 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-c48a9f2130ff4502a82b7c73a7971276 |
| 出典メモ | uspto-grants-1980_11 |