Hydrochloric Acid → HCID 86745006、化合物

HRID 2249011ノート

反応式

HRID 2249011 の反応式
[F:1][C:2]1[C:7]([C@@H:8]([OH:10])[CH3:9])=[C:6]([F:11])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[F:14].[CH3:15][S:16](Cl)(=[O:18])=[O:17].C(N(CC)CC)C.Cl>CCOCC>[CH3:15][S:16]([O:10][C@H:8]([C:7]1[C:2]([F:1])=[C:3]([F:14])[C:4]([F:13])=[C:5]([F:12])[C:6]=1[F:11])[CH3:9])(=[O:18])=[O:17]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 6993305S(-)-1-(PENTAFLUOROPHENYL)ETHANOL

生成物 1

HCID 86745006HCID 86745006、化合物収率 83%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To an ice-cooled solution of 0.21 g (1 mmol) of (S)-(-)-1-(pentafluorophenyl)ethanol and 0.17 g (1.5 mmol) of methanesulfonyl chloride in 2 m(of ether, was added dropwise 0.22 m((1.6 mmol) of triethylamine. After it was stirring for two hours at room temperature, 1N hydrochloric acid was added to the reaction mixture and was extracted with ether. This ether solution was washed with 1N hydrochloric acid and an aqueous solution of 5 wt% potassium carbonate , and the solvent was distilled off under reduced pressure. The subsequent distillation gave 0.24 g (yield: 83%) of (S)-(-)-1-(pentafluorophenyl)ethyl methanesulfonate having the aforementioned physical properties.

後処理

  1. extractionwas extracted with ether
  2. washThis ether solution was washed with 1N hydrochloric acid
  3. distillationan aqueous solution of 5 wt% potassium carbonate , and the solvent was distilled off under reduced pressure
  4. distillationThe subsequent distillation

出典と根拠

ORDレコード
ord-af6fd32cc21e4a2bb4f90e213a92cc3c
出典データセット
uspto-grants-1991_08
特許番号
US05041641

反応ノート

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