Isopropanol → 2,5-Diamino-4-chlorotoluene

HRID 2249029ノート

反応式

HRID 2249029 の反応式
C(O)(C)C.[Cl:5][C:6]1[CH:12]=[C:11]([N+:13]([O-])=O)[C:10]([CH3:16])=[CH:9][C:7]=1[NH2:8].[OH-].[K+]>C1(=O)C=CC=CC1=O.O>[Cl:5][C:6]1[CH:12]=[C:11]([NH2:13])[C:10]([CH3:16])=[CH:9][C:7]=1[NH2:8]

参加物

6

反応物 3

HCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 199955122-Chloro-5-methyl-4-nitroaniline

生成物 1

HCID 791932,5-Diamino-4-chlorotoluene収率 91.4%

試薬・触媒・溶媒 2

HCID 114211,2-Benzoquinone触媒HCID 962Water溶媒

実験手順

A reaction vessel was charged with 60 g of isopropyl alcohol, 50 g of water, 37.3 g of 2-chloro-5-methyl-p-nitroaniline, 5 g of potassium hydroxide and 0.6 g of 1,2-benzoquinone, and then the same procedure as in Example 1 was followed, to obtain 28.6 g of 2-chloro-5-methyl-p-phenylenediamine.

出典と根拠

ORDレコード
ord-c43e1bca86e541418a193be20c01b78a
出典データセット
uspto-grants-1991_08
特許番号
US05041672

反応ノート

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