関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Carbonazidic acid, 1,1-dimethylethyl ester | HCID 61256 | — |
| 反応物 | 2-[5-(Acetamidomethyl)thiophen-2-yl]acetic acid | HCID 23330367 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-[5-({[(Tert-butoxy)carbonyl]amino}methyl)thiophen-2-yl]aceticacid | HCID 20293281 | — |
反応手順
0.3 ml of a 2 N aqueous sodium hydroxide solution is added to a solution of 0.6 g of 2-(5-acetylaminomethyl-2-thienyl)-acetic acid in 5 ml of dioxane. The mixture is stirred for 12 hours at 55°-60° C. and cooled to 25° C., 0.2 ml of tert.-butoxycarbonyl azide is added, the mixture is stirred for 16 hours at room temperature and 2-(5-tert.-butoxycarbonylaminomethyl-2-thienyl)-acetic acid is isolated in accordance with the process described above.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04234578 |
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| 出典データセット | uspto-grants-1980_11 |
|---|
| ORD ID | ord-e16cd6a4384745fe8755233708ca10f0 |
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| 出典メモ | uspto-grants-1980_11 |
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