Ipriflavone → Ipriflavon beta-cyclodextrin

HRID 2249147

反応式

HRID 2249147 の反応式
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][O:11][C:9]=2[CH:10]=1)[CH3:3].[CH2:22]([OH:98])[C@H:23]1[O:28][C@@H:27]2[O:29][C@H:30]3[C@H:35]([OH:36])[C@@H:34]([OH:37])[C@@H:33]([O:38][C@H:39]4[C@H:44]([OH:45])[C@@H:43]([OH:46])[C@@H:42]([O:47][C@H:48]5[C@H:53]([OH:54])[C@@H:52]([OH:55])[C@@H:51]([O:56][C@H:57]6[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:60]([O:65][C@H:66]7[C@H:71]([OH:72])[C@@H:70]([OH:73])[C@@H:69]([O:74][C@H:75]8[C@H:81]([OH:82])[C@@H:80]([OH:83])[C@@H:78]([O:79][C@H:24]1[C@H:25]([OH:97])[C@H:26]2[OH:96])[O:77][C@@H:76]8[CH2:84][OH:85])[O:68][C@@H:67]7[CH2:86][OH:87])[O:59][C@@H:58]6[CH2:88][OH:89])[O:50][C@@H:49]5[CH2:90][OH:91])[O:41][C@@H:40]4[CH2:92][OH:93])[O:32][C@@H:31]3[CH2:94][OH:95]>>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][O:11][C:9]=2[CH:10]=1)[CH3:1].[CH2:88]([OH:89])[C@H:58]1[O:59][C@@H:60]2[O:65][C@H:66]3[C@H:71]([OH:72])[C@@H:70]([OH:73])[C@@H:69]([O:74][C@H:75]4[C@H:81]([OH:82])[C@@H:80]([OH:83])[C@@H:78]([O:79][C@H:24]5[C@H:25]([OH:97])[C@@H:26]([OH:96])[C@@H:27]([O:29][C@H:30]6[C@H:35]([OH:36])[C@@H:34]([OH:37])[C@@H:33]([O:38][C@H:39]7[C@H:44]([OH:45])[C@@H:43]([OH:46])[C@@H:42]([O:47][C@H:48]8[C@H:53]([OH:54])[C@@H:52]([OH:55])[C@@H:51]([O:56][C@H:57]1[C@H:62]([OH:63])[C@H:61]2[OH:64])[O:50][C@@H:49]8[CH2:90][OH:91])[O:41][C@@H:40]7[CH2:92][OH:93])[O:32][C@@H:31]6[CH2:94][OH:95])[O:28][C@@H:23]5[CH2:22][OH:98])[O:77][C@@H:76]4[CH2:84][OH:85])[O:68][C@@H:67]3[CH2:86][OH:87]

参加物

3

反応物 2

HCID 3747Ipriflavone2 回HCID 444041beta-Cyclodextrin

生成物 1

HCID 131715935Ipriflavon beta-cyclodextrin

実験手順

11.0 g (39.2 mmoles) of Ipriflavon and 114.3 g (88.3 mmoles) of β-cyclodextrin of 12.36% moisture content, were dissolved in 2.25 liters of 50% by volume aqueous ethanol solution at 80° C. under vigorous stirring and left to cool to room temperature. The crystalline product precipitated was filtered and dried for 24 hours at 60° C. to give 96.4 g of product in form of loose, white powder. The particle size is smaller than 90 μm. Ipriflavon content: 10.8% by weight; Ipriflavon: -β-cyclodextrin ratio=1:2; Yield related to the active ingredient: 94.7%.

後処理

  1. customYield

出典と根拠

ORDレコード
ord-12bf7adae4cc4939816d721b8761da78
出典データセット
uspto-grants-1991_08
特許番号
US05043326

関連ノート

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