Acetyl chloride → N-[(1S,2S)-2-Hydroxycyclopentyl]acetamide

反応式

[NH2:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[OH:7].[C:8](Cl)(=[O:10])[CH3:9]>>[OH:7][C@H:3]1[CH2:4][CH2:5][CH2:6][C@@H:2]1[NH:1][C:8](=[O:10])[CH3:9]

参加物

反応物 2

HCID 6367Acetyl chloride

HCID 11571787(1S,2S)-2-Aminocyclopentanol

生成物 1

HCID 14988810N-[(1S,2S)-2-Hydroxycyclopentyl]acetamide

実験手順

Following the procedure of Example 2A, 74.7 g of (S,S)-(+)-2-aminocyclopentanol were reacted with acetyl chloride to provide 107.9 g of the title intermediate as an oil which crystallized upon cooling. NMR.

出典と根拠

ORDレコード: ord-5a457c89e5e443ada306c9b1088ca9ef
出典データセット: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05043341

反応ノート

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