Potassium Bicarbonate → HCID 19825784、化合物

HRID 2249209ノート

反応式

HRID 2249209 の反応式
C(O)(=O)C.C(O)(=O)C.[O:9]1[C:22]([CH3:24])([CH3:23])[CH:10]1[CH2:11][C:12]1[C:13]([OH:21])=[CH:14][C:15]([O:19][CH3:20])=[C:16]([CH:18]=1)[OH:17].C(=O)([O-])O.[K+]>CO>[OH:9][C:22]([CH:10]1[CH2:11][C:12]2[CH:18]=[C:16]([OH:17])[C:15]([O:19][CH3:20])=[CH:14][C:13]=2[O:21]1)([CH3:24])[CH3:23]

参加物

4

反応物 2

HCID 516893Potassium BicarbonateHCID 86745023HCID 86745023、化合物

生成物 1

HCID 19825784HCID 19825784、化合物収率 80.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 5-(2,3-epoxy-3-methylbutyl)-2-methoxyhydroquinone diacetate (1.848 g) in methanol (36 ml) was added potassium hydrogencarbonate (1.50 g) in one portion. The mixture was stirred for 21 hours at ambient temperature and concentrated in vacuo. The residue was dissolved in a mixture of ethyl acetate (30 ml) and saturated sodium chloride solution (30 ml). The separated organic layer was washed with saturated sodium chloride solution, dried, and evaporated to dryness. The oily residue was crystallized from isopropyl ether to yield 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-6-methoxy-5-benzofuranol (964 mg) as a white solid.

後処理

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in a mixture of ethyl acetate (30 ml) and saturated sodium chloride solution (30 ml)
  3. washThe separated organic layer was washed with saturated sodium chloride solution
  4. customdried
  5. customevaporated to dryness
  6. customThe oily residue was crystallized from isopropyl ether

出典と根拠

ORDレコード
ord-0e5d249d524f410ab85b84892ca7cddc
出典データセット
uspto-grants-1991_08
特許番号
US05043354

反応ノート

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