Water → HCID 86613843、化合物

HRID 2249393ノート

反応式

HRID 2249393 の反応式
C([NH:4][C:5]1[CH:10]=[C:9]([I:11])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[C:6]=1[Cl:16])(=O)C.C(Cl)(=O)C.O>CO>[NH2:4][C:5]1[CH:10]=[C:9]([I:11])[N:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[C:6]=1[Cl:16]

参加物

5

反応物 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 86613844HCID 86613844、化合物

生成物 1

HCID 86613843HCID 86613843、化合物収率 78.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To solution of 4-acetylamino-3-chloro-6-iodopyridine-2-carboxylic acid, methyl ester (5.0 g, 14 mmol) in methanol (25 mL) was added acetyl chloride (1 mL) and the solution heated under reflux for 1 hour. The solution was cooled and water (25 mL) added and the precipitate was collected. Recrystallization from methanol gave 4-amino-3-chloro-6-iodopyridine-2-carboxylic acid, methyl ester (3.5 g, 11 mmol) mp 152-153° C.

後処理

  1. temperaturethe solution heated
  2. temperatureunder reflux for 1 hour
  3. temperatureThe solution was cooled
  4. customthe precipitate was collected
  5. customRecrystallization from methanol

出典と根拠

ORDレコード
ord-8dbf45017adf4d5485826a09a4f97c34
出典データセット
uspto-grants-2008_01
特許番号
US07314849B2

反応ノート

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