化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Cyanide → alpha-Oxothiophen-2-acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 2-Thiopheneglyoxylic acid | HCID 77694 | — |
| 反応物 | 2-Thiophenecarbonyl chloride | HCID 78928 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | alpha-Oxothiophen-2-acetonitrile | HCID 80107 | — |
反応手順
A process for preparing thienylglyoxylic acid which comprises reacting thiophene carboxylic acid chloride with aqueous sodium cyanide in methylene chloride solvent and in the presence of a phase transfer catalyst to form thiophene carboxylic acid cyanide and then reacting said thiophene carboxylic acid cyanide with concentrated hydrochloric acid at a temperature and for a time sufficient to form thienylglyoxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04234737 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-00e6599292844ef0b8b889a075c4bd4e |
| 出典メモ | uspto-grants-1980_11 |