4-(3-Hydroxypropylamino)-3-nitropyridine → 3-Amino-4-(3-hydroxypropylamino)pyridine

HRID 22495ノート

反応式

HRID 22495 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[N+:12]([O-])=O>C(O)C.[Ni]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH2:3][CH2:2][OH:1]

参加物

4

反応物 1

HCID 5923304-(3-Hydroxypropylamino)-3-nitropyridine

生成物 1

HCID 190429283-Amino-4-(3-hydroxypropylamino)pyridine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

4-(3-Hydroxypropylamino)-3-nitropyridine (4.12 g, 20.9 mmol) was dissolved in ethanol (130 ml) and Raney nickel (411 mg, 7.0 mmol) added. The stirred mixture was hydrogenated for 3 days. The catalyst was removed by filtration under argon and the solvent removed under reduced pressure to give 3-amino-4-(3-hydroxypropylamino)pyridine as a brown oil which was used directly in the next step.

後処理

  1. customThe catalyst was removed by filtration under argon
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-4c30fde3bc5e4f7d969c58ff09cd5573
出典データセット
uspto-grants-1995_06
特許番号
US05428168

反応ノート

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