Hydrazine → HCID 178498204、化合物

反応式

[CH3:1][O:2][C:3]([C:5]1[N:6]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=[C:8]([C:10](=S)[NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:13]=2[F:19])[CH:9]=1)=[O:4].[NH2:25][NH2:26]>C(Cl)Cl.CCO>[CH3:1][O:2][C:3]([C:5]1[N:6]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=[C:8]([C:10](=[N:25][NH2:26])[NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:13]=2[F:19])[CH:9]=1)=[O:4]

参加物

実験手順

To a solution of 4-(2,3-difluoro-phenylthiocarbamoyl)-1-methanesulfonyl-1H-pyrrole-2-carboxylic acid methyl ester (420 mg, 1.12 mmol) in CH2Cl2 (5 mL) and EtOH (5 mL) was added NH2NH2 (50 mg, 1.56 mmol) at room temperature. The mixture was stirred for 3 hours and the solvents were removed by evaporation under reduced pressure. The crude yellow solid product (410 mg, 98%) was dried on the pump for direct use. MS (ES+): m/e=373.1 (M+H); LC/Method A/2.70 min.