Methanol → 2-Methoxycarbonylamino-4-methyl valeric acid methyl ester

反応式

[CH3:1][O:2][C:3](=[O:10])[CH:4](Br)[CH2:5][CH:6]([CH3:8])[CH3:7].[O-:11][C:12]#[N:13].[K+].[CH3:15][OH:16]>>[CH3:1][O:2][C:3](=[O:10])[CH:4]([NH:13][C:12]([O:16][CH3:15])=[O:11])[CH2:5][CH:6]([CH3:8])[CH3:7]

参加物

反応物 3

HCID 887Methanol2 回

HCID 11378442Potassium cyanate2 回

HCID 12957039Methyl 2-bromo-4-methylpentanoate

生成物 1

HCID 140365862-Methoxycarbonylamino-4-methyl valeric acid methyl ester収率 66%

実験手順

14.64 grams of 2-bromo-4-methyl valeric acid methyl ester were brought to reaction with potassium cyanate and methanol in the manner described in Example 1 (using the same amounts of potassium cyanate and methanol as in Example 1 ), reaction time 1 hour and then worked up. There were obtained 9.39 grams (66%) of 2-methoxycarbonylamino-4-methyl valeric acid methyl ester with a boiling point of 100° C./0.0013 mbar.