2-[5-(2,4-Diisobutoxybenzoyl)-2-isobutoxyphenyl]acetic acid → 2-[5-(2,4-Diisobutoxybenzyl)-2-isobutoxyphenyl]acetic acid

HRID 2249618ノート

反応式

HRID 2249618 の反応式
[CH2:1]([O:5][C:6]1[CH:28]=[C:27]([O:29][CH2:30][CH:31]([CH3:33])[CH3:32])[CH:26]=[CH:25][C:7]=1[C:8]([C:10]1[CH:11]=[CH:12][C:13]([O:20][CH2:21][CH:22]([CH3:24])[CH3:23])=[C:14]([CH2:16][C:17]([OH:19])=[O:18])[CH:15]=1)=O)[CH:2]([CH3:4])[CH3:3].[H][H]>C(O)C.[C].[Pd]>[CH2:1]([O:5][C:6]1[CH:28]=[C:27]([O:29][CH2:30][CH:31]([CH3:33])[CH3:32])[CH:26]=[CH:25][C:7]=1[CH2:8][C:10]1[CH:11]=[CH:12][C:13]([O:20][CH2:21][CH:22]([CH3:24])[CH3:23])=[C:14]([CH2:16][C:17]([OH:19])=[O:18])[CH:15]=1)[CH:2]([CH3:4])[CH3:3]

参加物

5

反応物 2

HCID 178165642-[5-(2,4-Diisobutoxybenzoyl)-2-isobutoxyphenyl]acetic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 178164592-[5-(2,4-Diisobutoxybenzyl)-2-isobutoxyphenyl]acetic acid収率 72.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

In 2 ml of ethanol is dissolved 200 mg of 2-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]acetic acid. After adding 40 mg of 5% palladium-carbon, the mixture thus obtained is stirred at ambient temperature for one hour in a stream of hydrogen gas. The reaction mixture is filtered with Celite, and the solvent is distilled off under reduced pressure from the filtrate. The residue thus obtained is purified by silica gel column chromatography [eluent; n-hexane:ethyl acetate=4:1] to obtain 140 mg of 2-[5-(2,4-diisobutoxybenzyl)-2-isobutoxyphenyl]acetic acid as a colorless oily product.

後処理

  1. customthe mixture thus obtained
  2. filtrationThe reaction mixture is filtered with Celite
  3. distillationthe solvent is distilled off under reduced pressure from the filtrate
  4. customThe residue thus obtained
  5. customis purified by silica gel column chromatography [eluent; n-hexane:ethyl acetate=4:1]

出典と根拠

ORDレコード
ord-e810e911102646f3a6e08da4d5ce5858
出典データセット
uspto-grants-2008_01
特許番号
US07314888B1

反応ノート

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