Sodium Acetate → (3S)-8-(3-methylbutylidene)-1-thia-4-azaspiro[4.5]decane-3-carboxylic Acid

HRID 2249664ノート

反応式

HRID 2249664 の反応式
[CH3:1][CH:2]([CH3:12])[CH2:3][CH:4]=[C:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1.O.Cl.[NH2:15][C@@H:16]([C:19]([OH:21])=[O:20])[CH2:17][SH:18].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][CH:2]([CH3:12])[CH2:3][CH:4]=[C:5]1[CH2:10][CH2:9][C:8]2([S:18][CH2:17][C@H:16]([C:19]([OH:21])=[O:20])[NH:15]2)[CH2:7][CH2:6]1

参加物

6

反応物 3

HCID 517045Sodium AcetateHCID 10176341D-Cysteine hydrochloride monohydrateHCID 11636865HCID 11636865、化合物

生成物 1

HCID 68987170(3S)-8-(3-methylbutylidene)-1-thia-4-azaspiro[4.5]decane-3-carboxylic Acid収率 50%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

In a mixture of 3.5 ml of ethanol and 1.5 ml of water are dissolved 1.0 g of 4-(3-methylbutylidene)-1-cyclohexanone, 1.1 g of D-cysteine hydrochloride monohydrate and 0.52 g of sodium acetate. The resulting solution is stirred at ambient temperature for 2 hours. Water is added to the reaction mixture and the deposited crystal is collected by filtration. Thus, 0.81 g of (3S)-8-(3-methylbutylidene)-1-thia-4-azaspiro[4.5]decane-3-carboxylic acid is obtained as a colorless crystalline product.

後処理

  1. filtrationthe deposited crystal is collected by filtration

出典と根拠

ORDレコード
ord-53da8030ee984247b476023849f61499
出典データセット
uspto-grants-2008_01
特許番号
US07314888B1

反応ノート

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