Sec-Butylamine → 4-Sec-butylamino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde

HRID 2249722ノート

反応式

HRID 2249722 の反応式
Cl[C:2]1[C:7]([CH:8]=[O:9])=[C:6]([Cl:10])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[CH3:13][CH:14]([NH2:17])[CH2:15][CH3:16]>>[CH:14]([NH:17][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([Cl:10])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1)([CH2:15][CH3:16])[CH3:13]

参加物

3

反応物 2

HCID 24874Sec-ButylamineHCID 46140044,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

生成物 1

HCID 596395844-Sec-butylamino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde

実験手順

Prepared as described above in Example 2 starting from 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 2-butylamine to give the title compound 4-sec-butylamino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 0.87 (m, 3H), 1.18 (m, 3H), 1.20 (m, 2H), 2.51 (s, 3H), 4.24 (m, 1H), 9.12 (br s, 1H), 10.18 (s, 1H). LC MS (m/e)=260 (MH+).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-c762dd72367742eb9e6d4538aeef64c7
出典データセット
uspto-grants-2008_01
特許番号
US07314881B2

反応ノート

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