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(4-Fluoro-2-methylphenyl)boronic acid → 4-Sec-butylamino-6-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-Fluoro-2-methylphenyl)boronic acid | HCID 2734665 | — |
| 反応物 | 4-Sec-butylamino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde | HCID 59639584 | — |
| 生成物 | 4-Sec-butylamino-6-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde | HCID 59639559 | — |
反応手順
Prepared as described above in Example 11 starting from 4-sec-butylamino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 4-fluoro-2-methylphenylboronic acid to give the title compound 4-sec-butylamino-6-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 1.02 (m, 3H), 1.30 (m, 3H), 1.70 (m, 2H), 2.28 (m, 3H), 2.59 (s, 3H), 4.37 (m, 1H), 6.98 (m, 2H), 7.20 (m, 1H), 9.04 (br s, 1H), 9.50 (s, 1H). LC MS (m/e)=334 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07314881B2 |
| 出典データセット | uspto-grants-2008_01 |
| ORD ID | ord-631c15cc332e43bd8548fa18d88abede |
| 出典メモ | uspto-grants-2008_01 |