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Phthalic Anhydride → 7-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)heptanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phthalic Anhydride | HCID 6811 | — |
| 反応物 | 7-Aminoheptanoic acid | HCID 13580 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 7-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)heptanoic acid | HCID 13622635 | 50.8% |
反応手順
A mixture of phthalic anhydride (5.3 g.) and 7-amino-heptanoic acid (5.8 g.) was heated at 185°-190° C. for 40 minutes and then cooled. The cooled partially solidified product was dissolved in ethyl acetate and the solution washed several times with dilute HCl. The organic layer was dried (MgSO4), filtered and evaporated to dryness and the residue recrystallized from acetic acid to give 7-phthalimidoheptanoic acid (5 g.), m.p. 112°-115° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04234735 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-69f78c92517845a3a70f96df5c84e7fd |
| 出典メモ | uspto-grants-1980_11 |