2,4-Di-tert-butylphenol → 5,7-Di-tert-butyl-3-(4-hydroxyphenyl)benzofuran-2-one

関与物質

反応手順

A mixture of 103.2 g (0.50 mol) of 2,4-di-tert-butylphenol and 102.4 g (0.55 mol) of 4-hydroxymandelic acid monohydrate in 100 ml of acetic acid is refluxed under a nitrogen atmosphere for 24 hours. The reaction mixture is then diluted with 140 ml of 50% aqueous acetic acid, cooled, and the precipitate formed is filtered off. The residue is washed with a further 200 ml of 50% aqueous acetic acid and then dried to give 95.9 g (57%) of 5,7-di-tert-butyl-3-(4-hydroxyphenyl)benzofuran-2-one, m.p. 187°-190° C.

情報源と証拠