Hydrochloric Acid → 3,3-Dimethyl-5-oxopentanoic acid

HRID 225027ノート

反応式

HRID 225027 の反応式
[CH3:1][C:2]([CH3:12])([CH2:9][CH:10]=[O:11])[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[K+].Cl>CO.O>[CH3:1][C:2]([CH3:12])([CH2:9][CH:10]=[O:11])[CH2:3][C:4]([OH:6])=[O:5]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13050815Ethyl 4-formyl-3,3-dimethylbutanoate

生成物 1

HCID 30187243,3-Dimethyl-5-oxopentanoic acid収率 83.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of 1.50 g (8.71 mmol) of ethyl 3,3-dimethyl-5-oxopentanoate in 50 mL of methanol and 1 mL of water was added 1.0 g (17.8 mmol) of potassium hydroxide. The reaction mixture was stirred at room temperature for 411/2 hours. The reaction mixture was diluted with water and then made acidic by the addition of aqueous hydrochloric acid. The resulting solution was extracted with methylene chloride repeatedly. The combined organic layer was washed with an aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. Removal of the solvent afforded 1.05 g of 3,3-dimethyl-5-oxopentanoic acid, 84% crude yield. The nmr spectrum was consistent with the proposed structure.

後処理

  1. extractionThe resulting solution was extracted with methylene chloride repeatedly
  2. washThe combined organic layer was washed with an aqueous solution of sodium chloride
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customRemoval of the solvent

出典と根拠

ORDレコード
ord-cdee1cd4a5c54003b3686ee464a9b13d
出典データセット
uspto-grants-1980_11
特許番号
US04235780

反応ノート

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