Phthalimide → 2-(2-Oxocyclohexyl)isoindole-1,3-dione

HRID 2250497

反応式

HRID 2250497 の反応式
Cl[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8].[C:9]1(=[O:19])[NH:13][C:12](=[O:14])[C:11]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:10]12>>[O:8]=[C:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH:2]1[N:13]1[C:9](=[O:19])[C:10]2[C:11](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:12]1=[O:14]

参加物

3

反応物 2

HCID 6809PhthalimideHCID 132032-Chlorocyclohexanone

生成物 1

HCID 3226012-(2-Oxocyclohexyl)isoindole-1,3-dione

実験手順

The amine required as precursor was prepared in accordance with GB1131191. 2-Chlorocyclohexanone was reacted with phthalimide to give 2-(2-oxocyclohexyl)isoindole-1,3-dione, which was ketalized with ethylene glycol in the presence of para-toluenesulfonic acid, giving 2-(1,4-dioxaspiro[4.5]dec-6-yl)isoindole-1,3-dione. Treatment with hydrazine hydrate to remove the phthalimideradical gave the desired 1,4-dioxaspiro[4.5]dec-6-ylamine.

後処理

  1. customwas prepared in accordance with GB1131191

出典と根拠

ORDレコード
ord-0bd316679de54a07bf16492839134f58
出典データセット
uspto-grants-2008_01
特許番号
US07317033B2

関連ノート

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