Bromine → 5-Bromo-7-fluoro-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one
反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[C:7]2([CH3:14])[CH3:13].C([O-])(=O)C.[Na+].[Br:20]Br>C(Cl)Cl>[Br:20][C:4]1[CH:5]=[C:6]2[C:10](=[C:2]([F:1])[CH:3]=1)[N:9]([CH3:11])[C:8](=[O:12])[C:7]2([CH3:14])[CH3:13]参加物
5
反応条件
- 温度
- 25 °C
実験手順
7-Fluoro-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one (0.10 g, 0.52 mmol) was dissolved in 5 mL of CH2Cl2 and sodium acetate (47 mg, 0.56 mmol) was added followed by bromine (0.029 mL, 0.56 mmol). The mixture was stirred at 25° C. for 16 h then loaded directly onto a silica gel column. The column was eluted with 250 mL of CH2Cl2 and 250 mL 5% Acetone/CH2Cl2 to provide the title compound (116 mg) as a white solid (82%).
後処理
- washThe column was eluted with 250 mL of CH2Cl2 and 250 mL 5% Acetone/CH2Cl2
出典と根拠
- ORDレコード
- ord-8df9bd0ec6af41e5b2b6cf6b42eba172
- 出典データセット
- uspto-grants-2008_01
- 特許番号
- US07317037B2
反応ノート
読み込み中…