HCID 11516200、化合物 → HCID 11550765、化合物
反応式
[C:1]([C:3]1[N:4](C(OC(C)(C)C)=O)[C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[C:15]([F:17])[CH:16]=2)[NH:13][C:12](=[O:18])[C:11]3([CH3:20])[CH3:19])=[CH:6][CH:7]=1)#[N:2]>CC(N(C)C)=O.C(OCC)(=O)C>[F:17][C:15]1[CH:16]=[C:8]([C:5]2[NH:4][C:3]([C:1]#[N:2])=[CH:7][CH:6]=2)[CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:18])[C:11]2([CH3:20])[CH3:19]参加物
4
反応条件
- 温度
- 180 °C
実験手順
tert-butyl 2-cyano-5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1H-pyrrole-1-carboxylate (0.18 g, 0.50 mmol) was dissolved in 10 mL of dimethylacetamide and the solution was heated to 180° C. for 1 h. The mixture was cooled, diluted with ethyl acetate and washed with water, saturated aqueous NaCl, dried over MgSO4, and concentrated. Flash chromatography (25% acetone/hexane) afforded 0.121 g (91%) of the title compound as a white solid.