化工社化工社 化学情報印刷レポート · 研究参考用
1,3-Diphenyl-2-propanone → 3,5-diphenyl-4(1H)-pyridone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Diphenyl-2-propanone | HCID 7593 | — |
| 反応物 | Ethyl formate | HCID 8025 | — |
| 反応物 | 2H-Pyran-2-one | HCID 68154 | — |
| 反応物 | Disodium | HCID 141233 | — |
| 反応物 | 3,5-diphenyl-4H-pyran-4-one | HCID 282189 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | 3,4-Pentadien-2-one | HCID 10931367 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | 1,5-Dihydroxy-2,4-diphenyl-1,4-pentadien-3-one | HCID 70583784 | — |
| 生成物 | 3,5-diphenyl-4(1H)-pyridone | HCID 12466680 | — |
反応手順
The compounds of this invention can be prepared by various synthetic routes. Benary and Bitter, Ber. 61, 1058 (1928) taught the synthesis of an intermediate disodium salt of 1,5-dihydroxy-2,4-diphenyl-1,4-pentadien-3-one by the condensation of 1,3-diphenyl-2-propanone with ethyl formate in the presence of sodium methoxide. The intermediate pentadienone is neutralized by strong acid and forms 3,5-diphenyl-4-pyrone. Reaction of the pyrone with ammonium acetate at an elevated temperature produces 3,5-diphenyl-4(1H)-pyridone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04235619 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-71f7ef29a27d43e28876c9581594424d |
| 出典メモ | uspto-grants-1980_11 |