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Lithium Hydroxide → 2-Indancarboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | 2,2-Dicarboethoxy-indane | HCID 11010777 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Indancarboxylic Acid | HCID 575777 | 71% |
反応手順
Dissolve 2,2-dicarboethoxy-indan (5.67 g, 21.7 mmol) in ethanol (150 mL). Add 1N lithium hydroxide (50 mL) and stir overnight at room temperature. Reflux for 1 hour and concentrate the solution in vacuo. Partition between ethyl acetate and 6N hydrochloric acid. Separate the organic phase and wash with brine. Dry (MgSO4) and evaporate the solvent in vacuo to give an off-white solid. Distill (120°-160° C. @0.2-0.5 mmHg) to give 2-carboxy-indan (2.5 g, 71%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428158 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-288d66e56e5748a3accfe02165bd1989 |
| 出典メモ | uspto-grants-1995_06 |