Ethanol → Ethyl 3-methyl-3-azabicyclo[3.1.0]hexane-1-carboxylate
反応式
Cl.Cl.[CH2:3]([O:5][C:6]([C:8]12[CH2:13][CH:12]1[CH2:11][N:10]([CH3:14])[CH2:9]2)=N)[CH3:4].C([OH:17])C>O>[CH2:3]([O:5][C:6]([C:8]12[CH2:13][CH:12]1[CH2:11][N:10]([CH3:14])[CH2:9]2)=[O:17])[CH3:4]参加物
4
実験手順
Crude 3-methyl-3-azabicyclo[3.1.0]hexane-1-carboximidic acid ethyl ester dihydrochloride (obtained as described below) is boiled under reflux for 3 hours in 30 ml of ethanol and 0.6 ml of water. After evaporation, the resultant residue is made alkaline with an aqueous sodium bicarbonate solution. Extraction with methylene chloride gives the title compound (M.Pt. of napthalene-1,5-disulphonate 161°-165°).
後処理
- customAfter evaporation
- extractionExtraction with methylene chloride
出典と根拠
- ORDレコード
- ord-c5c1528743eb49af88960be021bdc813
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04235921
反応ノート
読み込み中…