Water → 3-Methyl-3-azabicyclo[3.1.0]hexane-1-carboxylic acid
反応式
[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]#N)([CH2:5]2)[CH2:3]1.[OH-:10].[K+].[OH2:12]>>[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]([OH:12])=[O:10])([CH2:5]2)[CH2:3]1参加物
4
実験手順
A solution of 10 g of 3-methyl-3-azabicyclo[3.1.0]-hexane-1-carbonitrile is 60 ml of saturated ethanolic KOH and 20 ml of water is boiled under reflux for 15 hours. After neutralization with hydrochloric acid the mixture is evaporated and the title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°).
後処理
- temperatureunder reflux for 15 hours
- customAfter neutralization with hydrochloric acid the mixture is evaporated
- extractionthe title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°)
出典と根拠
- ORDレコード
- ord-1f7c16e7d879450b9f9cf03cf27fb9d0
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04235921
反応ノート
読み込み中…