3-Chloro-2-methylaniline → 2-{[(3-Chloro-2-methylphenyl)imino]methyl}phenol

HRID 225179

反応式

HRID 225179 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:10][C:11]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:12]=1[NH2:13]>C(O)C>[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[N:13][C:12]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:11]=1[CH3:10]

参加物

4

反応物 2

HCID 68943-Chloro-2-methylanilineHCID 6998Salicylaldehyde

生成物 1

HCID 2963922-{[(3-Chloro-2-methylphenyl)imino]methyl}phenol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

o-Hydroxybenzaldehyde (0.20 mole) was treated with 2-methyl-3-chloroaniline (0.20 mole) with vigorous stirring in a 1 liter Erlenmeyer flask. After 15 mins., 33 cc of 95% ethanol was added and the reaction mixture was stirred vigorously for an additional 45 mins. The reaction mixture was left standing at room temperature for 10 min., then it was placed in an ice-bath for 0.5 hour. The crystals which formed were collected, washed with 95% ethanol, and air dried. Recrystallization from 85% ethanol gave N-(o-hydroxybenzylidene)-2-methyl-3-chloroaniline. m.p. 95°-97° C.

後処理

  1. stirringthe reaction mixture was stirred vigorously for an additional 45 mins
  2. waitThe reaction mixture was left
  3. waitstanding at room temperature for 10 min.
  4. waitit was placed in an ice-bath for 0.5 hour
  5. customThe crystals which formed
  6. customwere collected
  7. washwashed with 95% ethanol, and air
  8. customdried
  9. customRecrystallization from 85% ethanol

出典と根拠

ORDレコード
ord-c4cad60feea44fb8b0ecc89b55284f0c
出典データセット
uspto-grants-1980_11
特許番号
US04235929

関連ノート

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