Ether hydrochloride → (R)-7-Chloro-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine hydrochloride
反応式
Cl.C(OCC)C.[Cl:7][C:8]1[CH:39]=[CH:38][C:11]2[O:12][CH2:13][C:14]3[CH:37]=[CH:36][CH:35]=[CH:34][C:15]=3[N:16]([CH2:17][C@H:18]3[CH2:22][CH2:21][CH2:20][N:19]3[CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]4[O:31][CH2:32][O:33][C:27]=4[CH:26]=3)[C:10]=2[CH:9]=1>ClCCl>[ClH:7].[Cl:7][C:8]1[CH:39]=[CH:38][C:11]2[O:12][CH2:13][C:14]3[CH:37]=[CH:36][CH:35]=[CH:34][C:15]=3[N:16]([CH2:17][C@H:18]3[CH2:22][CH2:21][CH2:20][N:19]3[CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]4[O:31][CH2:32][O:33][C:27]=4[CH:26]=3)[C:10]=2[CH:9]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
3.0 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-7-chloro-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (0.63 g) in dichloromethane (5 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was stirred in hexane to obtain the title compound in the form of a light brown solid (348 mg, 89%).