Ether hydrochloride → (R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251890ノート

反応式

HRID 2251890 の反応式
[ClH:1].C(OCC)C.[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[CH:31][CH:30]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1>ClCCl>[ClH:1].[ClH:1].[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][C:32]([N:35]4[CH2:36][CH2:37][CH2:38][CH2:39]4)=[CH:33][CH:34]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1

参加物

4

反応物 2

HCID 10953452Ether hydrochlorideHCID 59644017(R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

生成物 1

HCID 69199662(R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

20 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (2.29 g) in dichloromethane (30 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (2.17 g, 81%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

出典と根拠

ORDレコード
ord-2d74ee5d69dc4e049fc1c5f8d437f749
出典データセット
uspto-grants-2008_01
特許番号
US07320973B2

反応ノート

読み込み中…