Hydrogen chloride-ethyl acetate → (R)-2-Fluoro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-3-yl]dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251897ノート

反応式

HRID 2251897 の反応式
[ClH:1].C(OCC)(=O)C.[F:8][C:9]1[CH:39]=[CH:38][C:12]2[N:13]([C@@H:22]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][C:29]4[CH:34]=[CH:33][C:32]([N:35]([CH3:37])[CH3:36])=[CH:31][CH:30]=4)[CH2:23]3)[C:14]3[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=3[O:16][CH2:17][C:11]=2[CH:10]=1>ClCCl>[ClH:1].[ClH:1].[F:8][C:9]1[CH:39]=[CH:38][C:12]2[N:13]([C@@H:22]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][C:29]4[CH:30]=[CH:31][C:32]([N:35]([CH3:36])[CH3:37])=[CH:33][CH:34]=4)[CH2:23]3)[C:14]3[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=3[O:16][CH2:17][C:11]=2[CH:10]=1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69199280(R)-2-fluoro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-3-yl]dibenzo-[b,e][1,4]oxazepine

生成物 1

HCID 69200791(R)-2-Fluoro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-3-yl]dibenzo[b,e][1,4]oxazepine dihydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.0 ml of 4 M hydrogen chloride/ethyl acetate was added to a solution of (R)-2-fluoro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-3-yl]dibenzo[b,e][1,4]oxazepine (140 mg) in dichloromethane (5 ml), and they were stirred together for 1 hour. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane and then filtered to obtain the title compound in the form of a light yellow solid (145 mg, 90%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-b5a330dec8244479949d150f7f555b2a
出典データセット
uspto-grants-2008_01
特許番号
US07320973B2

反応ノート

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