Ether hydrochloride → (r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251901ノート

反応式

HRID 2251901 の反応式
[ClH:1].C(OCC)C.[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1>ClCCl>[ClH:1].[ClH:1].[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1

参加物

4

反応物 2

HCID 10953452Ether hydrochlorideHCID 12990604(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

生成物 1

HCID 69201019(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.0 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-5,11-dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (208 mg) in dichloromethane (2 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a light brown solid (220 mg, 91%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

出典と根拠

ORDレコード
ord-3e3623e7f1c44c4aa5e093cb67b95be7
出典データセット
uspto-grants-2008_01
特許番号
US07320973B2

反応ノート

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