Benzene → Oxazolidine, 3-(dichloroacetyl)-2,2-dimethyl-
反応式
[CH3:1][C:2]1([CH3:7])[NH:6][CH2:5][CH2:4][O:3]1.C1C=CC=CC=1.C(N(CC)CC)C.[Cl:21][CH:22]([Cl:26])[C:23](Cl)=[O:24]>O>[CH3:1][C:2]1([CH3:7])[N:6]([C:23](=[O:24])[CH:22]([Cl:26])[Cl:21])[CH2:5][CH2:4][O:3]1参加物
6
実験手順
Five and one-tenth (5.1 g.) grams of 2,2-dimethyl oxazolidine dissolved in 50 ml. of benzene was treated with 5.5 g. of triethylamine and 7.4 g. of dichloroacetyl chloride was added dropwise with stirring and cooling in an ice bath. The mixture was poured into water, the benzene solution separated, dried over anhydrous magnesium sulfate and the solvent stripped under vacuum. The product was a waxy solid which had a melting point of 113°-115° C. on recrystallization from diethyl ether.
後処理
- temperaturecooling in an ice bath
- customthe benzene solution separated
- dry with materialdried over anhydrous magnesium sulfate
- customon recrystallization from diethyl ether
出典と根拠
- ORDレコード
- ord-8c374c1c40bf439d9bf38fefb1b35619
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04236011
反応ノート
読み込み中…