Benzene → Oxazolidine, 3-(dichloroacetyl)-2,2-dimethyl-

HRID 225224

反応式

HRID 225224 の反応式
[CH3:1][C:2]1([CH3:7])[NH:6][CH2:5][CH2:4][O:3]1.C1C=CC=CC=1.C(N(CC)CC)C.[Cl:21][CH:22]([Cl:26])[C:23](Cl)=[O:24]>O>[CH3:1][C:2]1([CH3:7])[N:6]([C:23](=[O:24])[CH:22]([Cl:26])[Cl:21])[CH2:5][CH2:4][O:3]1

参加物

6

反応物 4

HCID 241BenzeneHCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 5506972,2-Dimethyl-oxazolidine

生成物 1

HCID 11492198Oxazolidine, 3-(dichloroacetyl)-2,2-dimethyl-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Five and one-tenth (5.1 g.) grams of 2,2-dimethyl oxazolidine dissolved in 50 ml. of benzene was treated with 5.5 g. of triethylamine and 7.4 g. of dichloroacetyl chloride was added dropwise with stirring and cooling in an ice bath. The mixture was poured into water, the benzene solution separated, dried over anhydrous magnesium sulfate and the solvent stripped under vacuum. The product was a waxy solid which had a melting point of 113°-115° C. on recrystallization from diethyl ether.

後処理

  1. temperaturecooling in an ice bath
  2. customthe benzene solution separated
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customon recrystallization from diethyl ether

出典と根拠

ORDレコード
ord-8c374c1c40bf439d9bf38fefb1b35619
出典データセット
uspto-grants-1980_11
特許番号
US04236011

関連ノート

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