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Acetic Anhydride → 3-Hydroxy-3'-(trifluoromethyl)acrylophenone acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 3-Hydroxy-3'-(trifluoromethyl)acrylophenone sodium salt | HCID 70590370 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Hydroxy-3'-(trifluoromethyl)acrylophenone acetate | HCID 70477828 | — |
反応手順
A suspension of 12.0 g. of 3-hydroxy-3'-(trifluoromethyl)acrylophenone sodium salt in 75 ml. of dioxane and 10 ml. of acetic anhydride is stirred at room temperature for 2 hours and then poured into water. The precipitate is collected by filtration, dissolved in methylene chloride and then passed through a hydrous magnesium silicate column as described in Example 1, giving the desired product, m.p. 55°-5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236005 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-ce7f085a7a9b4a418043979685cee370 |
| 出典メモ | uspto-grants-1980_11 |