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3-Dimethylamino-3'-trifluoromethylacrylophenone → 2-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 反応物 | HCID 178434678 | HCID 178434678 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 15042084 | — |
反応手順
A mixture of 24.3 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 150 ml. of glacial acetic acid and 12.2 g. of 3-methyl-5-aminopyrazole-4-carbonitrile is refluxed for 6 hours and then evaporated. The residue is treated as described in Example 1, giving the desired product, m.p. 149°-150° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236005 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-7e4cf7ca5cff4ce0be2a6e84e95206d3 |
| 出典メモ | uspto-grants-1980_11 |