化工社化工社 化学情報印刷レポート · 研究参考用
3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 反応物 | HCID 178418806 | HCID 178418806 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine | HCID 19756203 | — |
反応手順
A mixture of 8.31 g. of 3-aminopyrazole, 24.32 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 100 ml. of glacial acetic acid is refluxed for 8 hours and evaporated in vacuo to an oil. This oil is treated as described in Example 1, giving the desired product, m.p. 103°-104.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236005 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-b7406f825afd4748944c91433263895e |
| 出典メモ | uspto-grants-1980_11 |