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3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 反応物 | HCID 178469928 | HCID 178469928 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester | HCID 11198437 | — |
反応手順
A mixture of 5.0 g. of 3-amino-4-carbethoxypyrazole and 7.84 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone in 25 ml. of glacial acetic acid is refluxed for 6 hours and then evaporated in vacuo to an oil. This oil is treated as described in Example 1, giving the desired product, m.p. 97°-99° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236005 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-f3e7d24f0dc44fdfbf25a2df623d7cf4 |
| 出典メモ | uspto-grants-1980_11 |