3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

HRID 225269

反応式

HRID 225269 の反応式
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O.[NH2:42][C:43]1[C:47](C#N)=[C:46]([C:50]#[N:51])[NH:45][N:44]=1>>[C:43]([C:47]1[C:46]([C:50]#[N:51])=[N:45][N:44]2[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=[N:2][C:17]=12)#[N:42]

参加物

4

反応物 3

HCID 3388303-amino-1H-pyrazole-4,5-dicarbonitrileHCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

生成物 1

HCID 113704003-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

実験手順

A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is reacted with trifluoroacetic anhydride to give the product of the example.

後処理

  1. additionA mixture of 4.86 g
  2. customthe solvent removed under reduced pressure
  3. customThe residue is reacted with trifluoroacetic anhydride
  4. customto give the product of the example

出典と根拠

ORDレコード
ord-8a041eab68fa4b0f9476f8937d90c71f
出典データセット
uspto-grants-1980_11
特許番号
US04236005

関連ノート

読み込み中…