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5-amino-1H-imidazole-4-carbonitrile → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-amino-1H-imidazole-4-carbonitrile | HCID 78777 | — |
| 反応物 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile | HCID 15712556 | — |
反応手順
A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 0.01 mole of 4-amino-5-imidazolecarbonitrile in 30 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed under reduced pressure and worked up as for Example 29 to give the product as crystals, m.p. 168°-169° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236005 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-662297a6590c445487fb32c1e108f620 |
| 出典メモ | uspto-grants-1980_11 |