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5-Aminoimidazole-4-carboxamide hydrochloride → 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Aminoimidazole-4-carboxamide hydrochloride | HCID 66146 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 3-Dimethylamino-3'-methoxyacrylophenone | HCID 42573796 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-(m-Methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide | HCID 14677474 | — |
反応手順
A mixture of 1.62 g. of 4-amino-5-imidazolecaboxamide hydrochloride, 3-dimethylamino-3'-methoxyacrylophenone, 0.82 g. of sodium acetate and 25 ml. of glacial acetic acid is refluxed for 10 hours. The mixture is evaporated to dryness and the residue worked up to give 4-(m-methoxyphenyl)imidazo[1,5-a]pyrimidine-8-carboxamide. This compound is treated as for Example 29 with trifluoroacetic anhydride to give the product of the example.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04236005 |
| 出典データセット | uspto-grants-1980_11 |
| ORD ID | ord-12c217d117a749b1a77ed7237de14d30 |
| 出典メモ | uspto-grants-1980_11 |