Hydrochloric Acid → Ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-amide

HRID 2252727

反応式

HRID 2252727 の反応式
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH3:16])=[C:6]([Cl:17])[N:5]=[C:4]([C:18]2[N:23]=[CH:22][CH:21]=[CH:20][N:19]=2)[N:3]=1.[K+].[CH2:25]([S:27]([NH-:30])(=[O:29])=[O:28])[CH3:26].Cl>CS(C)=O>[Cl:17][C:6]1[N:5]=[C:4]([C:18]2[N:23]=[CH:22][CH:21]=[CH:20][N:19]=2)[N:3]=[C:2]([NH:30][S:27]([CH2:25][CH3:26])(=[O:29])=[O:28])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 105457064,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidineHCID 59645266Ethanesulfonamide potassium salt

生成物 1

HCID 59645271Ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-amide収率 83.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To a solution of 4,6-dichloro-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl (prepared as described in [6] and [11]) (1.74 g) in DMSO (5 ml) was added ethanesulfonamide potassium salt (1.62 g). Stirring was continued for 10 days at rt. The reaction mixture was poured onto ice/water and acidified by 2N HCl. The precipitate was filtered off, washed with water and dried at HV to give ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yl]-amide (1.75 g) as a white powder. LC-MS: tR: 3.77, [M+H]+: 422.15.

後処理

  1. additionThe reaction mixture was poured onto ice/water
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried at HV

出典と根拠

ORDレコード
ord-1833bfeb75884697a5a22960994186ed
出典データセット
uspto-grants-2008_01
特許番号
US07323465B2

関連ノート

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